| Rabbit Anti-Myozenin 1 antibody |
| 反应物种（预测） |
Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep |
| 产品应用（已验证） |
IHC |
| 产品应用（可尝试） |
ELISA |
| 推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:400-800, |
| 研究领域 |
心血管,细胞生物,信号转导 |
| 标签 |
Array |
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Paraformaldehyde-fixed, paraffin embedded (rat heart); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Myozenin 1) Polyclonal Antibody, Unconjugated (bs-24598R ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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Paraformaldehyde-fixed, paraffin embedded (human heart); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Myozenin 1) Polyclonal Antibody, Unconjugated (bs-24598R ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
RRID：RRID
产品名称：Rabbit Anti-Myozenin 1 antibody
别名： MYOZ1; Myozenin; myozenin 1; Myozenin-1; Calsarcin-2; Filamin, actinin and telethonin binding protein; actinin- and telethonin-binding protein; MYOZ1_MOUSE; Protein FATZ; CS 2; FATZ; Protein FATZ; Calsarcin 2.
中文名称：MYOZ抗体
英文名称：Rabbit Anti-Myozenin 1 antibody
抗体来源： Rabbit
克隆类型：多克隆
细胞定位：细胞核
性 状：Liquid
亚 型：IgG
纯化方法：affinity purified by Protein A
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原：KLH conjugated synthetic peptide derived from human Myozenin 1
抗原表位：1-100/299
SWISS：Q9JK37
Gene ID ：59011
Human Gene ID：59011
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. MYOZ (Myozenin 1) plays an important role in the modulation of calcineurin signaling. MYOZ1 may play a role in myofibrillogenesis. MYOZ1 interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP and interacts via its C-terminal region with MYOT. MYOZ1 is localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. MYOZ1 colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle. MYOZ1 is expressed primarily in skeletal muscle and specifically enriched in the gastrocnemius, which is composed predominantly of fast-twitch muscle fibers.
Function：Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of
Subunit：Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT.
Subcellular Location：Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.
Tissue Specificity：Expressed primarily in skeletal muscle and specifically enriched in the gastrocnemius, which is composed predominantly of fast-twitch muscle fibers. Detected at lower levels in heart.
Similarity：Belongs to the myozenin family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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