免 疫 原：KLH conjugated synthetic peptide derived from human PDGF-D/SCDGFB
抗原表位：1-100/370
SWISS：Q9GZP0
Gene ID ：80310
Human Gene ID：80310

SCDGFB (Spinal cord derived growth factor B) is a member of the platelet derived growth factor family. It only forms homodimers and does not dimerize with the other three family members. It is a potent mitogen for cells of mesenchymal origin. It is activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet derived growth factor receptor. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. It induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.
Function：Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophag
Subunit：Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
Subcellular Location：Secreted. Note=Released by platelets upon wounding.
Tissue Specificity：Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A wides
Post-translational modifications：Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator
Similarity：Belongs to the PDGF/VEGF growth factor family.
Contains 1 CUB domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.