免 疫 原：KLH conjugated synthetic peptide derived from human HMGCR
SWISS：P04035
Gene ID ：3156
Human Gene ID：3156

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Function：This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.
Subunit：Homodimer.
Subcellular Location：Endoplasmic reticulum membrane. Peroxisome membrane.
Similarity：Belongs to the HMG-CoA reductase family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.