免 疫 原：KLH conjugated synthetic peptide derived from human SIRT2
抗原表位：261-360/389
SWISS：Q8IXJ6
Gene ID ：22933
Human Gene ID：22933

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Function：NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
Subcellular Location：Cytoplasm, cytoskeleton. Colocalizes with microtubules.
Tissue Specificity：Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulatio
Post-translational modifications：Phosphorylated at the G2/M transition of the cell cycle.
Similarity：Belongs to the sirtuin family.
Contains 1 deacetylase sirtuin-type domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.