Rabbit Anti-Tartrate Resistant Acid Phosphatase antibody |
反应物种(预测) |
Mouse,Rat |
产品应用(已验证) |
WB |
推荐稀释比例 |
WB=1:500-2000, |
研究领域 |
肿瘤,细胞生物,免疫学,信号转导 |
标签 |
Array |
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Sample:
Lane 1: U251 (Human) Cell Lysate at 30 ug
Lane 2: A549 (Human) Cell Lysate at 30 ug
Lane 3: HepG2 (Human) Cell Lysate at 30 ug
Primary: Anti-Tartrate Resistant Acid Phosphatase (bs-22944R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 36 kD
RRID:RRID
产品名称:Rabbit Anti-Tartrate Resistant Acid Phosphatase antibody
别名: Type 5 acid phosphatase; Acid phosphatase 5 tartrate resistant; ACP5; PPA5_HUMAN; T5ap; Tartrate resistant acid ATPase; Tartrate resistant acid phosphatase type 5; Tartrate resistant acid phosphatase type 5 precursor; Tartrate-resistant acid ATPase; Tartr
中文名称:抗酒石酸酸性磷酸酶5型/5型酸性磷酸酶抗体
英文名称:Rabbit Anti-Tartrate Resistant Acid Phosphatase antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞浆
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human Tartrate Resistant Acid Phosphatase
抗原表位:211-310/325
SWISS:P13686
Gene ID :54
Human Gene ID:54
Tartrate-resistant acid phosphatase is an iron containing glycoprotein that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. TRAP is the most basic of the acid phosphatases and is the only form not inhibited by L+-tartrate. TRAP is a relatively minor lysosomal enzyme which may be activated in certain pathologies such as Hodgkin’s disease and B- and T-cell leukemias. Receptor activator of NFκB ligand (RANKL) plays an essential role in osteoclast differentiation and activation by increasing the expression of protease osteoclast markers such as TRAP. TRAP has collagenolytic activity and plays a major role in ligament degradation.
Function:Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Subunit:Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).
Subcellular Location:Lysosome.
DISEASE:Defects in ACP5 are the cause of spondyloenchondrodysplasia with immune dysregulation (SPENCDI) [MIM:607944]. A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune
Similarity:elongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.