免 疫 原：KLH conjugated synthetic peptide derived from human CaIPLA2
抗原表位：331-430/806
SWISS：O60733
Gene ID ：8398
Human Gene ID：8398

The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010].
Function：Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas
Subunit：Forms large oligomeric 270-350 kDa structures.
Subcellular Location：Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.
Isoform SH-iPLA2: Cytoplasm.
Tissue Specificity：Four different transcripts were found to be expressed in a distinct tissue distribution.
DISEASE：Defects in PLA2G6 are the cause of neurodegeneration with brain iron accumulation type 2B (NBIA2B) [MIM:610217]. A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by progressiv
Similarity：Contains 7 ANK repeats.
Contains 1 patatin domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.