免 疫 原：KLH conjugated synthetic peptide derived from human Periplakin
抗原表位：1-100/1756
SWISS：O60437
Gene ID ：5493
Human Gene ID：5493

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
Function：Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.
Subcellular Location：Cell junction > desmosome. Cytoplasm > cytoskeleton. Cell membrane. Nucleus. Mitochondrion. Associated with desmosomes and intermediate filaments.
Tissue Specificity：Expressed in stratified squamous epithelia and in some other epithelia.
Similarity：Belongs to the plakin or cytolinker family.
Contains 2 plectin repeats.
Contains 4 spectrin repeats.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.