免 疫 原：KLH conjugated synthetic peptide derived from human KGF
抗原表位：32-110/194
SWISS：P21781
Gene ID ：2252
Human Gene ID：2252

KGF is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
Function：Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cel
Subunit：Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
Subcellular Location：Secreted.
Tissue Specificity：Epithelial cell.
Similarity：Belongs to the heparin-binding growth factors family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.