免 疫 原：KLH conjugated synthetic peptide derived from mouse MT-ND6
抗原表位：31-130/172
SWISS：P03923
Gene ID ：4541
Human Gene ID：4541

NADH Dehydrogenase subunit 6 (MTND6) is 1 of the 7 mitochondrial DNA (mtDNA) encoded subunits (MTND1, MTND2, MTND3, MTND4L, MTND4, MTND5, MTND6) included among the approximately 41 polypeptides of respiratory Complex I. Complex I accepts electrons from NADH, transfers them to ubiquinone (Coenzyme Q10), and uses the energy released to pump protons across the mitochondria inner membrane. MTND6 has been proposed to be a component of the iron-protein fragment.
Function：Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The
Subcellular Location：Mitochondrion membrane; Multi-pass membrane protein (Potential).
DISEASE：Defects in MT-ND6 are a cause of Leber hereditary optic neuropathy (LHON) [MIM:535000]. LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurologic
Similarity：Belongs to the complex I subunit 6 family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.