免 疫 原：KLH conjugated synthetic peptide derived from human KIF18B
抗原表位：121-220/864
SWISS：Q86Y91
Gene ID ：146909
Human Gene ID：146909

The Kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual Kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events, including endocytosis and transcytosis. KIF18B (kinesin family member 18B) is an 864 amino acid nuclear and cytoplasmic protein that belongs to the kinesin-like protein family. Containing one kinesin-motor domain, KIF18B is dominantly expressed in amygdala. During mitosis, KIF18B is suggested to be closely associated with astral microtubules emanating from the spindle pole during prometaphase and metaphase. KIF18B may play an important role in regulating cell division. KIF18B exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 17q21.31.
Function：May play an important role in regulating cell division.
Subunit：Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robus
Subcellular Location：Cytoplasmic, Nuclear and Plasma membrane
Tissue Specificity：Shows a prominent expression in the amygdala.
Similarity：Belongs to the kinesin-like protein family.
Contains 1 kinesin-motor domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.