免 疫 原：KLH conjugated synthetic peptide derived from human Cyclin A1
抗原表位：391-465/465
SWISS：P78396
Gene ID ：8900
Human Gene ID：8900

Cyclin A1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin A1 is expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. It binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. Cyclin A1 was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins.
Function：Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
Subcellular Location：Nucleus. Cytoplasm. Cytoplasmic when associated with SCAPER.
Similarity：Belongs to the cyclin family. Cyclin AB subfamily.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.