Rabbit Anti-MNX1/HLXB9 antibody |
反应物种(预测) |
Rat,Chicken,Dog,Pig,Cow,Rabbit |
产品应用(已验证) |
WB |
产品应用(可尝试) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
研究领域 |
肿瘤,细胞生物,发育生物学,神经生物学,表观遗传学, |
标签 |
Array |
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Sample:
Molt-4(Human) Cell Lysate at 30 ug
MCF-7(Human) Cell Lysate at 30 ug
A549t(Human) Cell Lysate at 30 ug
K562(Human) Cell Lysate at 30 ug
Pancreas(Mouse) Lysate at 40 ug
Primary: Anti-MNX1/HLXB9 (bs-22522R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 48 kD
Observed band size: 48 kD
RRID:RRID
产品名称:Rabbit Anti-MNX1/HLXB9 antibody
别名: HB9/HLXB9; HB 9; HB9; HLXB 9; HLXB9; Homeo box HB9; Homeobox HB9; Homeobox protein HB9; HOXHB9; MNX1; MNX1_HUMAN; Motor neuron and pancreas homeobox protein 1; Sacral agenesis autosomal dominant (Currarino triad); SCRA 1; SCRA1; SCRA1; HOXHB9.
中文名称:运动神经元及胰腺同源蛋白1抗体
英文名称:Rabbit Anti-MNX1/HLXB9 antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞核
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human MNX1/HLXB9
抗原表位:201-300/401
SWISS:P50219
Gene ID :3110
Human Gene ID:3110
The HB9 homeobox transcription factor regulates gene expression during embryonic development and also in specific adult tissues. HB9 gene mutations are implicated in Curriano syndrome, which is characterized by a triad consisting of a presacral tumor, sacral agenesis and anorectal malformation. In human bone marrow cells, HB9 expression directly correlates with CD34 expression. Furthermore, HB9 expression increases in CD34+ cells that are treated with IL-3 and granulocyte macrophage-colony-stimulating factor. Early in murine development, HB9 is expressed in pancreatic buds (dorsal and ventral) with subsequent expression in differentiating beta cells in the islets of Langerhans. The dorsal lobe of the pancreas fails to form in HB9(-) mice; the resultant pancreas has smaller islets of Langerhans and less beta cells than normal pancreas. The HB9 gene is expressed in the human adult pancreas. In the developing vertebrate embryo, the HB9 gene plays an essential role in motor neuron differentiation. The motor columns of HB9(-) mice are disorganized, lacking phrenic and abducens nerves and exhibiting intercostal nerve defects.
Function:Putative transcription factor involved in pancreas development and function.
Subcellular Location:Nucleus.
Tissue Specificity:Expressed in lymphoid and pancreatic tissues.
DISEASE:Defects in MNX1 are a cause of Currarino syndrome (CURRAS) [MIM:176450]. The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic de
Similarity:Contains 1 homeobox DNA-binding domain.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.