免 疫 原：KLH conjugated synthetic peptide derived from human IL-23R
抗原表位：231-330/629
抗原细胞定位：Extracellular
SWISS：Q5VWK5
Gene ID ：149233
Human Gene ID：149233

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
Function：Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and ad
Subcellular Location：Cell membrane; Single-pass type I membrane protein.
Tissue Specificity：Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Post-translational modifications：Phosphorylated in response to IL23.
DISEASE：Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative c
Similarity：Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 2 fibronectin type-III domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.