免 疫 原：KLH conjugated synthetic peptide derived from human hydrogen exchanger 3
抗原表位：581-680/834
抗原细胞定位：Cytoplasmic
SWISS：P48764
Gene ID ：6550
Human Gene ID：6550

NHE-3 are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics. NHE-3 localizes to the apical membrane of renal proximal tubules where it is responsible for most of the sodium transport and fluid reabsorption. NHE-3 translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. NHE-3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells.
Function：Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Subunit：Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels
Subcellular Location：Membrane. In intestinal epithelial cells, localizes to the ileal brush border.
Post-translational modifications：Phosphorylated by PKA, which inhibits activity.
Similarity：Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.