免 疫 原：KLH conjugated synthetic peptide derived from human CD163
抗原表位：551-650/1156
抗原细胞定位：Extracellular
SWISS：Q86VB7
Gene ID ：9332
Human Gene ID：9332

The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Function：Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, vi
Subcellular Location：Secreted and Cell membrane. Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.
Tissue Specificity：Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed a
Post-translational modifications：A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease
Similarity：Contains 9 SRCR domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.