免 疫 原：KLH conjugated synthetic peptide derived from human ASBT/SLC10A2
抗原表位：131-230/348
抗原细胞定位：Extracellular
SWISS：Q12908
Gene ID ：6555
Human Gene ID：6555

SLC10A2 plays a critical role in reabsorption of bile acids from the the small intestine lumen. Passive flow of sodium ions down their concentration gradient is coupled to bile acid movement, resulting in an increase in the concentration of bile acids in the interior of the cell. This action conserves the body's pool of re-circulating bile acid. SLC10A2 also plays a key role in cholesterol metabolism as cholesterol is the precursor molecule in bile acid synthesis mediated by CYP7A and FXR.
Function：Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.
Subunit：Monomer and homodimer.
Subcellular Location：Membrane; Multi-pass membrane protein.
DISEASE：Primary bile acid malabsorption (PBAM) [MIM:613291]: An intestinal disorder associated with chronic watery diarrhea, excess fecal bile acids, steatorrhea and interruption of the enterohepatic circulation of bile acids. {ECO:0000269|PubMed:9109432}. Note=T
Similarity：Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.