免 疫 原：KLH conjugated synthetic peptide derived from human CD9
抗原表位：101-200/228
抗原细胞定位：Extracellular
SWISS：P21926
Gene ID ：928
Human Gene ID：928

CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. It belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). It also regulates cell motility in a variety of cell lines, and appears to be an important regulator of Schwann cell behaviour in peripheral nerve.
Function：Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.
Subunit：Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8.
Subcellular Location：Membrane; Multi-pass membrane protein.
Tissue Specificity：Expressed by a variety of hematopoietic and epithelial cells.
Post-translational modifications：Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.
Similarity：Belongs to the tetraspanin (TM4SF) family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.