Rabbit Anti-p53 BP3 antibody |
反应物种(预测) |
Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep |
产品应用(已验证) |
WB |
推荐稀释比例 |
WB=1:500-2000, |
研究领域 |
肿瘤,细胞生物,细胞周期蛋白,表观遗传学,泛素, |
标签 |
Array |
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Sample:
Lane 1: A549 (Human) Cell Lysate at 30 ug
Lane 2: Hela (Human) Cell Lysate at 30 ug
Lane 3: Jurkat (Human) Cell Lysate at 30 ug
Lane 4: A431 (Human) Cell Lysate at 30 ug
Primary: Anti-p53 BP3 (bs-21069R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 119/112 kD
Observed band size: 119 kD
RRID:RRID
产品名称:Rabbit Anti-p53 BP3 antibody
别名: AW105885;
E3 ubiquitin protein ligase Topors;
E3 ubiquitin-protein ligase Topors;
LUN;
p53 binding protein 3;
p53 BP3/LUN;
p53-binding protein 3;
p53BP3;
p53BP3/LUN;
Retinitis pigmentosa 31;
RP31;
SUMO1 protein E3 ligase Topors;
SUMO1-protein
中文名称:p53结合蛋白3抗体
英文名称:Rabbit Anti-p53 BP3 antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞核
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human p53 BP3
抗原表位:21-120/1045
SWISS:Q9NS56
Gene ID :10210
Human Gene ID:10210
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]
Function:Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chro
Subcellular Location:Nucleus. Nucleus > PML body. Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
Tissue Specificity:Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and
Post-translational modifications:Phosphorylation at Ser-98 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the SUMO1-protein ligase activity resulting in inc
DISEASE:Defects in TOPORS are the cause of retinitis pigmentosa type 31 (RP31) [MIM:609923]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progres
Similarity:Contains 1 RING-type zinc finger.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.