免 疫 原：KLH conjugated synthetic peptide derived from human ZFR
抗原表位：271-370/1074
SWISS：Q96KR1
Gene ID ：51663
Human Gene ID：51663

ZFR is 1,074 amino acid RNA-binding protein. In human, ZFR is expressed in lung, liver, lymphocytes, heart, pancreas, kidney and placenta, and regulates postimplantation and gastrulation stages of development. Murine ZFR is observed in testis, ovary and brain. With elevated levels of expression during meiosis, ZFR associates with chromosome foci in meiotic cells. ZFR contains 1 DZF domain and localizes in the somatodendritic compartment of hippocampal neurons and colocalizes with STAU2 in cytosolic RNA granules. Knockout of ZFR in mouse embryo prevents the development of some embryonic structures leads to an increase in programmed cell death with a decrease in mitotic index.
Function：Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA.
Subcellular Location：Nucleus. Cytoplasm. Cytoplasmic granule. Chromosome. Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules.
Tissue Specificity：Expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain and kidney.
Similarity：Contains 1 DZF domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.