Rabbit Anti-SV2C antibody |
反应物种(预测) |
Human,Pig,Rabbit |
产品应用(已验证) |
IHC |
产品应用(可尝试) |
ICC,IF,ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
研究领域 |
细胞生物,神经生物学,信号转导,通道蛋白 |
标签 |
Array |
RRID:RRID
产品名称:Rabbit Anti-SV2C antibody
别名: Synaptic vesicle protein 2c; SV2C_HUMAN.
中文名称:突触泡蛋白2C抗体
英文名称:Rabbit Anti-SV2C antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞膜
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human SV2C
抗原表位:451-550/727
抗原细胞定位:Extracellular
SWISS:Q496J9
Gene ID :22987
Human Gene ID:22987
In all vertebrates, SV2 proteins are abundant, hydrophobic, membrane glycoproteins that are expressed as two major isoforms, SV2A and SV2B, and one minor isoform, SV2C. SV2 proteins are differentially expressed in the brain and are present on all synaptic vesicles, independent of transmitter type. SV2A is abundantly expressed in the subcortex, specifically in the synaptic vesicles of all presynaptic nerve terminals, and also in most neuroendocrine secretory granules. SV2B displays a more restricted pattern of expression in that it is only present on a small subset of synapses in the hippocampus and cortex. SV2A and SV2B are funtionally redundant and are required for maintaining normal brain function in vertebrates. SV2A and SV2B mediate synaptic transmission by regulating cytoplasmic Ca2+ levels in the nerve terminal during repetitive stimulation.
Function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
Subunit:Interacts with SYT1 in a calcium-dependent manner (By similarity).
Subcellular Location:Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity). Note=Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and
Post-translational modifications:N-glycosylated (By similarity).
Similarity:Belongs to the major facilitator superfamily.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.