Rabbit Anti-OTOA antibody |
反应物种(预测) |
Human,Rat |
产品应用(已验证) |
WB |
产品应用(可尝试) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
研究领域 |
神经生物学,细胞粘附分子,细胞外基质, |
标签 |
Array |
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Sample:
Testis (Mouse) Lysate at 40 ug
Primary: Anti-OTOA (bs-11060R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 150 kD
Observed band size: 150 kD
RRID:RRID
产品名称:Rabbit Anti-OTOA antibody
别名: Cancer/testis antigen 108; CT108; Deafness, autosomal recessive 22; DFNB22; OTOA; OTOAN_HUMAN; Otoancorin.
中文名称:耳聋、常染色体隐性遗传22抗体
英文名称:Rabbit Anti-OTOA antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞膜,细胞外基质,分泌型蛋白
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human OTOA/DFNB22
抗原表位:231-330/1153
SWISS:Q7RTW8
Gene ID :146183
Human Gene ID:146183
Otoancorin, also known as OTOA, CT108 or DFNB22, is a 1,153 amino acid protein belonging to the stereocilin family. Expressed in the inner ear and restricted to the interface between the apical surface of sensory epithelia, otoancorin is suggested to act as an adhesion molecule. Otoancorin ensures the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in the gene encoding otoancorin leads to deafness autosomal recessive type 22 (DFNB22), which is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain or the area of the brain that receives sound information. Existing as three alternatively spliced isoforms, otoancorin is encoded by a gene located on human chromosome 16p12.2.
Function:May act as an adhesion molecule.
Subcellular Location:Apical cell membrane. Secreted > extracellular space > extracellular matrix. At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes.
DISEASE:Defects in OTOA are the cause of deafness autosomal recessive type 22 (DFNB22) [MIM:607039]. DFNB22 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the bra
Similarity:Belongs to the stereocilin family.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.