免 疫 原：KLH conjugated synthetic peptide derived from human ANKRD13A
抗原表位：161-260/590
SWISS：Q8IZ07
Gene ID ：88455
Human Gene ID：88455

Function：Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the
Subunit：Interacts (via the UIM 3 and 4 repeats) with EGFRc(ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization.
Subcellular Location：Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane.
Post-translational modifications：Monoubiquitinated, inhibits interaction with ubiquitinated EGFR.
Similarity：Contains 2 ANK repeats.
Contains 3 UIM (ubiquitin-interacting motif) repeats.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.