免 疫 原：KLH conjugated synthetic peptide derived from human GPR124
抗原表位：1201-1303/1303
SWISS：Q96PE1
Gene ID ：25960
Human Gene ID：25960

Tumor endothelial markers (TEMs) display elevated expression during angiogenesis. Their associations with the cell surface membrane are of great interest for both biological and clinical research. G protein coupled receptor 124 (GPR124) is encoded as a seven pass transmembrane protein of 1331 amino acids and is most similar to the cadherin related Celsr1 proteins and members of the calcium independent alpha latrotoxin receptor family involved in transmitting signals across the cell membrane. GPCRs have been excellent drug targets because their natural ligands can often mimicked for agonistic or antagonistic purpose. The existence of tumour specific endothelial markers provides a resource for further understanding the mechanisms of tumour angiogenesis and encourages the development of antiangiogenic therapies in the future. ESTs for the gene that encodes GPR124 have been isolated primarily from amnion, connective tissue, ear, embryo, eye, ganglion, heart, lung, placenta, and skin libraries.
Function：Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity).
Subunit：Interacts with DLG1.
Subcellular Location：Cell membrane; Multi-pass membrane protein.
Tissue Specificity：Expressed in endothelial cells (at protein level). Abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon.
Similarity：Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 4 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.