Rabbit Anti-Aminoacylase 1 antibody |
反应物种(预测) |
Human,Mouse,Pig,Cow,Horse |
产品应用(已验证) |
WB |
产品应用(可尝试) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
研究领域 |
免疫学,信号转导,通道蛋白,新陈代谢, |
标签 |
Array |
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Sample:
Lane 1: Spleen (Rat) Lysate at 40 ug
Lane 2: Small intestine (Rat) Lysate at 40 ug
Primary: Anti-Aminoacylase 1 (bs-6019R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 46 kD
Observed band size: 46 kD
RRID:AB_11050221
产品名称:Rabbit Anti-Aminoacylase 1 antibody
别名: ACY 1; ACY1; ACY1D; ACYLASE; EC 3.5.1.14; N acyl L amino acid amidohydrolase; ACY1_HUMAN.
中文名称:氨基酰化酶1抗体
英文名称:Rabbit Anti-Aminoacylase 1 antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞浆
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human ACY1/Aminoacylase 1
抗原表位:201-300/408
SWISS:Q03154
Gene ID :95
Human Gene ID:95
Aminoacylase 1 is a cytosolic, homodimeric, zinc binding enzyme that catalyzes the hydrolysis of acylated L amino acids to L amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase 1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc binding enzymes.
Function:Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
Subunit:Homodimer. Interacts with SPHK1.
Subcellular Location:Cytoplasm.
Tissue Specificity:Expression is highest in kidney, strong in brain and weaker in placenta and spleen.
DISEASE:Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D) [MIM:609924]. ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked mu
Similarity:Belongs to the peptidase M20A family.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.