免 疫 原：KLH conjugated synthetic peptide derived from human KLST/Kallistatin
抗原表位：151-250/427
SWISS：P29622
Gene ID ：5267
Human Gene ID：5267

Kallistatin is a serine proteinase inhibitor which binds to tissue kallikrein and inhibits its amidolytic and kininogenase activity. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.
Function：Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibi
Subunit：Monomer and some homodimers.
Subcellular Location：Secreted.
Tissue Specificity：Expressed by the liver and secreted in plasma.
Post-translational modifications：The N-terminus is blocked.
Similarity：Belongs to the serpin family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.