Rabbit Anti-LVRN antibody |
反应物种(预测) |
Rat,Dog |
产品应用(已验证) |
WB |
产品应用(可尝试) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
研究领域 |
细胞生物,发育生物学,跨膜蛋白,泛素,细胞膜蛋白, |
标签 |
Array |
RRID:RRID
产品名称:Rabbit Anti-LVRN antibody
别名: Laeverin/Aminopeptidase Q; EC:3.4.11.-;
AMPQ_HUMAN;
AP-Q;
APQ;
AQPEP;
CHL2 antigen;
Laeverin;
中文名称:氨肽酶Q抗体
英文名称:Rabbit Anti-LVRN antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞膜
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human LVRN
抗原表位:501-600/990
SWISS:Q6Q4G3
Gene ID :206338
Human Gene ID:206338
Laeverin is a 990 amino acid member of the peptidase M1 family and contains an HEXXHX18E gluzincin motif and an H(G)AMEN motif. Expressed specifically in placenta on embryo-derived extravillous trophoblasts (EVTs), laeverin localizes to the cell membrane and is a single-pass type II membrane protein. Laeverin binds zinc and functions as a bestatin-sensitive leucine aminopeptidase with a potential role in EVT function. This suggests that laeverin may be involved in human placentation, during which EVTs invade maternal decidua and spiral areteries. More specifically, laeverin may function by regulating the activities of key peptides at the embryo-maternal interface. Laeverin has a broad substrate specificity but exhibits a preference for Leu-4-methylcoumaryl-7-amide. In addition, laeverin can form a homodimer with intermolecular disulfide bond(s).
Function:Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-L
Subcellular Location:Membrane.
Tissue Specificity:Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected on eith
Post-translational modifications:N-glycosylated.
Similarity:Belongs to the peptidase M1 family.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.