| Rabbit Anti-GRAF antibody |
| 反应物种（预测） |
Chicken,Dog,Pig,Cow,Rabbit,Sheep |
| 产品应用（已验证） |
WB |
| 产品应用（可尝试） |
ELISA |
| 推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
| 研究领域 |
肿瘤,心血管,神经生物学,信号转导,细胞骨架,细胞外基质,G蛋白信号, |
| 标签 |
Array |
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Sample:
Cerebrum(Rat) Lysate at 40 ug
Cerebrum(Mouse) Lysate at 40 ug
Cerebellum(Rat) Lysate at 40 ug
HepG2(Human) Cell Lysate at 30 ug
Kidney(Rat) Lysate at 40 ug
Kidney(Mouse) Lysate at 40 ug
A549(Human) Cell Lysate at 30 ug
A431(Human) Cell Lysate at 30 ug
HL60(Human) Cell Lysate at 30 ug
U937(Human) Cell Lysate at 30 ug
Cerebellum(Mouse) Lysate at 40 ug
Primary: Anti-GRAF (bs-11248R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 38 kD
RRID：RRID
产品名称：Rabbit Anti-GRAF antibody
别名： arhgap 26; ARHGAP26; FLJ42530; GRAF; GRAF1; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); KIAA0621; oligophrenin 1 like protein; Oligophrenin-1-like protein; oligophrenin1like pr
中文名称：Rho GTP酶激活蛋白26抗体
英文名称：Rabbit Anti-GRAF antibody
抗体来源： Rabbit
克隆类型：多克隆
细胞定位：细胞浆,细胞膜
性 状：Liquid
亚 型：IgG
纯化方法：affinity purified by Protein A
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原：KLH conjugated synthetic peptide derived from human GRAF1
抗原表位：1-100/814
SWISS：Q9UNA1
Gene ID ：23092
Human Gene ID：23092
Cellular signaling by G-proteins is down-regulated by GTPase-activating proteins (GAPs), which increase the rate of GTP hydroylsis. The GTPase regulator associated with focal adhesion kinase (GRAF) has GAP activity toward Rho A and Cdc42, but not Rac1. GRAF is ubiquitously expressed with high levels in heart and brain. Expression of GRAF causes clearing of stress fibers and formation of long actin based filopodial-like extensions. Fusion of MLL with GRAF, MLL/GRAF, is included in a rare genetic subgroup of acute myeloid leukemia (AML) cases.
Function：GTPase-activating protein for RHOA and CDC42.
Subunit：Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.
Subcellular Location：Cell junction; focal adhesion. Cytoplasm; cytoskeleton. Colocalizes with actin stress fibers and cortical actin structures.
DISEASE：Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal t
Similarity：Contains 1 PH domain.
Contains 1 Rho-GAP domain.
Contains 1 SH3 domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
400-901-9800
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