| Rabbit Anti-DENTT antibody |
| 反应物种（预测） |
Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit |
| 产品应用（已验证） |
ICC |
| 产品应用（可尝试） |
WB,IHC,IF,ELISA |
| 推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100, |
| 研究领域 |
细胞生物,神经生物学,信号转导 |
| 标签 |
Array |
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Hela cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (DENTT) polyclonal Antibody, Unconjugated (bs-7051R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.
RRID：AB_11076823
产品名称：Rabbit Anti-DENTT antibody
别名： CASK interacting nucleosome assembly protein; CINAP; CDA1; Cell division autoantigen 1 nucleolar protein; CTCL tumor antigen se20-4; DENTT; Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa; TSPY-like 2; TSPY-like prot
中文名称：细胞分裂核仁蛋白1抗体
英文名称：Rabbit Anti-DENTT antibody
抗体来源： Rabbit
克隆类型：多克隆
细胞定位：细胞核,细胞浆
性 状：Liquid
亚 型：IgG
纯化方法：affinity purified by Protein A
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原：KLH conjugated synthetic peptide derived from human DENTT
抗原表位：251-350/693
SWISS：Q9H2G4
Gene ID ：64061
Human Gene ID：64061
CASK interacting nucleosome assembly protein (CINAP) modulates gene expression and its abundance in cultured neurons is regulated by synaptic activity. CINAP is widely expressed in different regions of adult mouse brain, including the cerebral cortex, hippocampus, striatum, hypothalamus, cerebellum, and two adult brain regions known to generate progenitor neurons. During early development, CINAP is also expressed in regions where neuronal progenitor cells are actively dividing, the ventricular and subventricular zones, suggesting that in addition to regulating gene expression in mature neurons CINAP may also play a role in dividing cells.
Function：Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
Subunit：Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2.
Subcellular Location：Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons.
Tissue Specificity：Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
Post-translational modifications：Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation (Probable).
Similarity：Belongs to the nucleosome assembly protein (NAP) family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
400-901-9800
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