免 疫 原：KLH conjugated synthetic peptide derived from human Frizzled 9/CD349
抗原表位：185-270/591
抗原细胞定位：Extracellular
SWISS：O00144
Gene ID ：8326
Human Gene ID：8326

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008]
Function：Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt
Subcellular Location：Cell membrane.
Tissue Specificity：Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney.
Post-translational modifications：Ubiquitinated by ZNRF3, leading to its degradation by the proteasome
Similarity：Belongs to the G-protein coupled receptor Fz/Smo family.
Contains 1 FZ (frizzled) domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.