Rabbit Anti-PHLP antibody |
反应物种(预测) |
Chicken,Pig,Horse,Rabbit |
产品应用(已验证) |
WB,IHC |
产品应用(可尝试) |
IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
研究领域 |
细胞生物,信号转导,G蛋白偶联受体,G蛋白信号, |
标签 |
Array |
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Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PHLP) Polyclonal Antibody, Unconjugated (bs-5812R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
RRID:AB_11116743
产品名称:Rabbit Anti-PHLP antibody
别名: PDCL;
Phosducin Like;
PhLP;
Phosducin-Like Protein;
PHLOP1; Phosducin like protein;
PhLP1; PHLP_HUMAN.
中文名称:光导蛋白样蛋白PDCL抗体
英文名称:Rabbit Anti-PHLP antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞浆
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human PHLP
抗原表位:51-150/301
SWISS:Q13371
Gene ID :5082
Human Gene ID:5082
Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
Function:Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Isoform 1:
Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 hetero
Subunit:Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.
Interacts with the CCT chaperonin complex.
Tissue Specificity:Expressed in buccal mucosa cell and 236 other tissues
Similarity:Belongs to the phosducin family.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.