免 疫 原：KLH conjugated synthetic peptide derived from human UGCG
抗原表位：31-98/394
SWISS：Q16739
Gene ID ：7357
Human Gene ID：7357

Glucosylceramide synthase (GCS), also designated ceramide glucosyltransferase, belongs to the glycosyltransferase 2 family. It is a widely expressed integral membrane protein encoded by UGCG. The enzyme can be found in the plasma membrane of all eukaryotic cells, and a significant concentration of glucosylceramide synthase activity has been reported in the Golgi complex. Glucosylceramide synthase catalyzes the first glycosylation step in glycosphingolipid biosynthesis and functions as a glucosyltransferase and flippase in the transfer of glucose to ceramide. Glucosylceramide synthase operates in cell recognition, cell proliferation and differentiation, immune recognition and signal transduction. The regulation of ceramide levels through glucosylceramide synthase has been associated with the induction of apoptosis and notable research implicates this relationship with drug-induced apoptosis in a variety of cell types.
Function：Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".
Subcellular Location：Golgi apparatus membrane.
Tissue Specificity：Found in all tissues examined.
Similarity：Belongs to the glycosyltransferase 2 family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.