免 疫 原：KLH conjugated synthetic peptide derived from human UCMA
抗原表位：21-120/138
SWISS：Q8WVF2
Gene ID ：221044
Human Gene ID：221044

UCMA is a 138 amino acid secreted protein that is highly expressed in resting chrondrocytes in developing long bones and is thought to function in the early phase of chrondrocyte differentiation. A furin-like protease processes UCMA into an N-terminal 37 amino acid peptide and a C-terminal 74 amino acid peptide, which is referred to as Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C). Introduction of recombinant Ucma-C interferes with osteogenic differentiation of mesenchymal stem cells, MC3T3-E1 preosteoblasts and primary osteoblasts. This suggests that Ucma may be involved in the negative regulation of osteogenic differentiation of osteochondrogenic precursor cells at the cartilage-bone interface and in peripheral zones of fetal cartilage.
Function：May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
Subcellular Location：Secreted > extracellular space > extracellular matrix.
Tissue Specificity：Predominantly expressed in resting chondrocytes.
Post-translational modifications：Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation.
Sulfated on tyrosine residues.
Similarity：Belongs to the UCMA family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.