免 疫 原：KLH conjugated synthetic peptide derived from human IL-10RA
抗原表位：81-180/578
抗原细胞定位：Extracellular
SWISS：Q13651
Gene ID ：3587
Human Gene ID：3587

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq].
Function：Receptor for IL10; binds IL10 with a high affinity.
Subcellular Location：Membrane; Single-pass type I membrane protein.
Tissue Specificity：Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.
DISEASE：Inflammatory bowel disease 28 (IBD28) [MIM:613148]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the ga
Similarity：Belongs to the type II cytokine receptor family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.