免 疫 原：KLH conjugated synthetic peptide derived from human TFDP1
抗原表位：221-320/410
SWISS：Q14186
Gene ID ：7027
Human Gene ID：7027

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
Function：The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis.
Subunit：Component of the E2F/DP transcription factor complex. Forms heterodimers with E2F family members. The complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that inhibit the E2F transactivation domain.
Subcellular Location：Nucleus.
Tissue Specificity：Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas.
Post-translational modifications：Phosphorylation by E2F-1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.
Similarity：Belongs to the E2F/DP family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.