免 疫 原：KLH conjugated synthetic peptide derived from human Legumain
抗原表位：201-300/433
SWISS：Q99538
Gene ID ：5641
Human Gene ID：5641

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008].
Function：Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
Subcellular Location：Lysosome (By similarity).
Tissue Specificity：Ubiquitous. Particularly abundant in kidney, heart and placenta.
Post-translational modifications：Glycosylated.
Similarity：Belongs to the peptidase C13 family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.