免 疫 原：KLH conjugated synthetic peptide derived from human SOCS6
抗原表位：21-120/535
SWISS：O14544
Gene ID ：9306
Human Gene ID：9306

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008].
Function：SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which m
Subunit：Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3. Interacts with KIT (phosphorylated).
Similarity：Contains 1 SH2 domain.
Contains 1 SOCS box domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.