免 疫 原：KLH conjugated synthetic peptide derived from human Histone H1.4
抗原表位：1-100/219
SWISS：P10412
Gene ID ：3008
Human Gene ID：3008

Histone H1b are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
Function：Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.
Subcellular Location：Nucleus. Chromosome.
Post-translational modifications：Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1.
Similarity：Belongs to the histone H1/H5 family.
Contains 1 H15 (linker histone H1/H5 globular) domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.