免 疫 原：KLH conjugated synthetic peptide derived from human P2RX7
抗原表位：115-160/595
抗原细胞定位：Extracellular
SWISS：Q99572
Gene ID ：5027
Human Gene ID：5027

The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP.
Function：The product P2RX7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activat
Subunit：Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB.
Subcellular Location：Cell membrane; Multi-pass membrane protein.
Post-translational modifications：Phosphorylation results in its inactivation.
ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel (By similarity).
Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for effic
Similarity：Belongs to the P2X receptor family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.