免 疫 原：KLH conjugated synthetic peptide derived from human UBF1
抗原表位：51-150/764
SWISS：P17480
Gene ID ：7343
Human Gene ID：7343

This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]
Function：Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.
Subcellular Location：Nucleus
Post-translational modifications：Phosphorylated and activated by PIK3CA.
Similarity：Contains 6 HMG box DNA-binding domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.