Rabbit Anti-LPA1 antibody |
反应物种(预测) |
Chicken,Dog,Cow,Horse,Sheep |
产品应用(已验证) |
WB |
产品应用(可尝试) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:2000-5000, |
研究领域 |
肿瘤,免疫学,信号转导,G蛋白偶联受体, |
标签 |
Array |
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Sample:Heart (Mouse)Lysate at 40 ug
Primary: Anti-LPA1(bs-2880R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41 kD
Observed band size: 44 kD
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Sample:Kidney(Mouse)Lysate at 40 ug
Primary: Anti-LPA1(bs-2880R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41 kD
Observed band size: 44 kD
RRID:AB_10855422
产品名称:Rabbit Anti-LPA1 antibody
别名: EDG 2; Endothelial Cell Differentiation Gene-2; Endothelial differentiation gene 2; Endothelial Differentiation Lysophosphatidic Acid G Protein Coupled Receptor 2; G10 protein homolog; GPCR 26; GPCR26; Gpcr91; Kdt2; LPA 1; LPA receptor 1; LPA receptor EDG
中文名称:溶血磷脂酸受体蛋白1/EDG2抗体
英文名称:Rabbit Anti-LPA1 antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞浆,细胞膜
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human EDG2/LPA1
抗原表位:281-364/364
抗原细胞定位:Cytoplasmic
SWISS:Q92633
Gene ID :1902
Human Gene ID:1902
EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several proteins not used within 12 hours. Edg2 has been reported in most human tissues, and is especially abundant in brain cortical regions. ESTs have been isolated from bone, brain, breast, connective tissue, embryo, heart/melanocyte/uterus, lung, prostate and uterus libraries.
Function:Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on
Subunit:Interacts with RALA and ADRBK1.
Subcellular Location:Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles.
Tissue Specificity:Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes.
Similarity:Belongs to the G-protein coupled receptor 1 family.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.