Rabbit Anti-Renin antibody |
反应物种(预测) |
Human,Dog,Cow,Horse |
产品应用(已验证) |
WB |
产品应用(可尝试) |
IHC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
研究领域 |
肿瘤,染色质和核信号,信号转导,转录调节因子,激酶和磷酸酶 |
标签 |
Array |
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Sample:
Lane 1: Mouse Kidney Lysates
Lane 2: Rat Kidney Lysates
Primary: Anti-Renin (bs-6184R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 37kDa
Observed band size: 37kDa
RRID:AB_11052931
产品名称:Rabbit Anti-Renin antibody
别名: Angiotensin forming enzyme; Angiotensin forming enzyme precursor; Angiotensinogenase; Angiotensinogenase precursor; HNFJ2; REN; Renin1; Renin-1; Renin 1; Ren1; RENI_HUMAN; Renin; Renin precursor renal.
中文名称:肾素/血管紧张素形成酶Ren1抗体
英文名称:Rabbit Anti-Renin antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞膜,分泌型蛋白
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human Renin
抗原表位:331-406/406
SWISS:P00797
Gene ID :5972
Human Gene ID:5972
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008].
Function:Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney
Subunit:Interacts with ATP6AP2.
Subcellular Location:Secreted. Membrane. Associated to membranes via binding to ATP6AP2.
DISEASE:Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
Similarity:Belongs to the peptidase A1 family.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.