免 疫 原：KLH conjugated synthetic peptide derived from human GCK
抗原表位：101-200/465
SWISS：P35557
Gene ID ：2645
Human Gene ID：2645

Hexokinases phosphorylate glucose to produce glucose 6 phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose 6 phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non insulin dependent diabetes mellitus, also called maturity onset diabetes of the young, type 2; mutations have also been associated with persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Function：Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the
Subunit：Monomer.
Tissue Specificity：Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
DISEASE：Defects in GCK are the cause of maturity-onset diabetes of the young type 2 (MODY2) [MIM:125851]; also shortened MODY-2. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (
Similarity：Belongs to the hexokinase family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.