免 疫 原：KLH conjugated synthetic peptide derived from human SLC40A1/FPN1
抗原表位：331-430/571
SWISS：Q9NP59
Gene ID ：30061
Human Gene ID：30061

SLC40A1 may be involved in iron export from duodenal epithelial cells and also in transfer of iron between maternal and fetal circulation. It mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4, an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin.
Function：May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
Subunit：Belongs to the S1LC40A transporter family.
Subcellular Location：Cell membrane. Localized to the basolateral membrane of polarized epithelial cells.
Tissue Specificity：Expressed in placenta, intestine, muscle and spleen.
DISEASE：Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevat
Similarity：Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.