货号 |
bsm-33859M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-IKB beta antibody |
中文名称 |
Mouse Anti-IKB beta antibody |
研究领域 |
肿瘤,免疫学,转录调节因子 |
英文别名 |
I kappa B beta; I-kappa-B-beta; IkappaBbeta; IKB beta; IkB-B; IkB-beta; IKBB; IKBB_HUMAN; IkBbeta; NF kappa BIB; NF-kappa-B inhibitor beta; NF-kappa-BIB; Nfkbib; Thyroid receptor interacting protein 9; Thyroid receptor-interacting protein 9; TR interactin |
反应物种(已验证) |
Mouse |
反应物种(预测) |
Human,Rat |
产品应用(已验证) |
WB |
推荐稀释比例 |
WB=1:1000-2000, |
克隆类型 |
单克隆 |
抗体来源 |
Mouse |
理论分子量 |
38 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Lyophilized or Liquid |
免疫原 |
Recombinant human IKB beta |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. |
Tissue |
Expressed in all tissues examined. |
SIMILARITY |
Belongs to the NF-kappa-B inhibitor family.
Contains 6 ANK repeats. |
SUBUNIT |
Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2. |
Function |
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent |
Post-translational |
Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. |
SWISS |
Q15653 |
Gene ID |
4793 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]. |