货号 |
bs-24711R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-EML4 antibody |
中文名称 |
Rabbit Anti-EML4 antibody |
研究领域 |
肿瘤,细胞生物,免疫学 |
英文别名 |
EML4; EML-4; C2orf2; Echinoderm microtubule associated protein like 4; Echinoderm microtubule-associated protein-like 4; ELP 120; ELP120; EMAL4_HUMAN; EMAP 4; EMAP-4; EMAP4; EML 4; eml4; Restrictedly overexpressed proliferation associated protein; Restric |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat |
产品应用(已验证) |
IHC |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:400-800, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
109 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human EML4-ALK fusion protein(EML4) |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm, cytoskeleton (Potential). Contains 9 WD repeats. |
SIMILARITY |
Belongs to the WD repeat EMAP family. |
Function |
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity). |
SWISS |
Q96HE3 |
Gene ID |
27436 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Microtubules are components of the Actin cytoskeleton that play crucial roles in cell morphogenesis, cell motility, spindle formation and chromosome movements. Echinoderm microtubule-associated (EML) proteins function to modify the assembly dynamics of microtubules. EML4 (Echinoderm microtubule-associated protein-like 4), also known as EMAPL4, ELP120, C2orf2 or ROPP120, is a 981 amino acid cytoplasmic protein that contains nine WD repeats. Expressed at high levels during mitosis, EML4 is thought to modify the assembly dynamics of microtubules, specifically altering microtubules to become longer and more flexible. Due to a chromosomal inversion with chromosome 2p, EML4 may exist as a fusion protein with ALK (anaplastic lymphoma receptor tyrosine kinase), producing an EML4-ALK fusion complex that plays a role in the pathogenesis of lung cancer. |