货号 |
bs-24572R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-PDGF-D/SCDGFB antibody |
中文名称 |
Rabbit Anti-PDGF-D/SCDGFB antibody |
研究领域 |
肿瘤,心血管,免疫学,神经生物学,信号转导,生长因子和激素 |
英文别名 |
IEGF; Iris expressed growth factor; Iris-expressed growth factor; MGC26867; MSTP036; PDGF D; PDGF-D; PDGFD; PDGFD latent form; PDGFD receptor-binding form; PDGFD_HUMAN; Platelet derived growth factor D; Platelet-derived growth factor D; receptor-binding f |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
41 |
细胞定位 |
分泌型蛋白 |
性状 |
Lyophilized or Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human PDGF-D/SCDGFB |
抗原表位 |
1-100/370 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Secreted. Note=Released by platelets upon wounding. |
Tissue |
Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A wides |
SIMILARITY |
Belongs to the PDGF/VEGF growth factor family. Contains 1 CUB domain. |
SUBUNIT |
Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. |
Function |
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophag |
Post-translational |
Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator |
SWISS |
Q9GZP0 |
Gene ID |
80310 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
SCDGFB (Spinal cord derived growth factor B) is a member of the platelet derived growth factor family. It only forms homodimers and does not dimerize with the other three family members. It is a potent mitogen for cells of mesenchymal origin. It is activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet derived growth factor receptor. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. It induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. |