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货号 | bs-24302R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-ATRX antibody |
中文名称 | Rabbit Anti-ATRX antibody |
研究领域 | 染色质和核信号,表观遗传学, |
英文别名 | Alpha thalassemia/mental retardation syndrome X linked homolog; ATP dependent helicase ATRX; ATP-dependent helicase ATRX; ATR2; Atrx; ATRX_HUMAN; DNA dependent ATPase and helicase; Helicase 2, X linked; MGC2094; MRXHF1; RAD54; RAD54L; SFM1; SHS; Transcrip |
反应物种(已验证) | Mouse,Rat |
反应物种(预测) | Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep |
产品应用(已验证) | WB |
产品应用(可推荐) | ELISA |
推荐稀释比例 | WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 283 |
细胞定位 | 细胞核 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic peptide derived from human ATRX |
抗原表位 | 131-230/2492 |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Nucleus |
Tissue | Ubiquitous. |
SIMILARITY | Belongs to the SNF2/RAD54 helicase family. Contains 1 ADD domain. Contains 1 GATA-type zinc finger. Contains 1 helicase ATP-binding domain. |
Function | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres an |
DISEASE | Alpha-thalassemia mental retardation syndrome, X-linked Mental retardation, X-linked, syndromic, with hypotonic facies 1 Alpha-thalassemia myelodysplasia syndrome |
SWISS | P46100 |
Gene ID | 546 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017] |