货号 |
bs-55187R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-RHOC antibody |
中文名称 |
Rabbit Anti-RHOC antibody |
研究领域 |
肿瘤 |
英文别名 |
ARH 9; ARH9; ARHC; H9; MGC1448; MGC61427; Oncogene RHO H9; Ras homolog gene family member C; RAS related homolog 9; RHO C; Rho cDNA clone 9; Rho related GTP binding protein RhoC; Rho-related GTP-binding protein RhoC; rhoC; RhoC GTPase; RHOC_HUMAN; RHOH 9; |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat |
产品应用(已验证) |
WB |
产品应用(可推荐) |
IHC,IF |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:50-100,IHC-F=1:450-100,IF=1:50-100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
22 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
Recombinant human RHOC |
抗原表位 |
1-193/193 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. |
SIMILARITY |
Belongs to the small GTPase superfamily. Rho family. |
SUBUNIT |
Interacts with RTKN. Interacts with AKAP13, DIAPH1, PKN2, ROCK1 and ROCK2. Interacts with ARHGDIA. |
Function |
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. |
SWISS |
P08134 |
Gene ID |
389 |
保存条件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |