货号 |
bsm-52506R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-S100 beta antibody |
中文名称 |
Rabbit Anti-S100 beta antibody |
产品标签 |
重组兔单抗 |
研究领域 |
肿瘤,细胞生物,神经生物学,细胞周期蛋白,细胞分化,表观遗传学, |
英文别名 |
NEF; Protein S100 B; Protein S100-B; S 100 calcium binding protein beta chain; S 100 protein beta chain; S 100 protein beta subunit; S-100 protein beta chain; S-100 protein subunit beta; S100; S100 calcium binding protein B; S100 calcium binding protein b |
反应物种(已验证) |
Mouse,Rat,Zebrafish |
反应物种(预测) |
Human |
产品应用(已验证) |
WB,IHC,ICC |
产品应用(可推荐) |
IP |
推荐稀释比例 |
WB=1:500-2000,IP=1:10-50,IHC-P=1:50-200,IHC-F=1:50-200,ICC=1:50, |
克隆类型 |
单克隆 |
克隆号 |
26C3 |
抗体来源 |
Rabbit |
理论分子量 |
10 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human S100B |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. |
Tissue |
Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. |
SIMILARITY |
Belongs to the S-101 family.
Contains 2 EF-hand domains. |
SUBUNIT |
Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38 (By similarity). The S100B dimer interacts with two molecules of CAPZA1. |
Function |
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high |
SWISS |
P04271 |
Gene ID |
6285 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
S100 beta is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. |