货号 |
bs-22896R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-DDX4 antibody |
中文名称 |
Rabbit Anti-DDX4 antibody |
研究领域 |
细胞生物,免疫学 |
英文别名 |
DDX 4; DEAD (Asp Glu Ala Asp) box polypeptide 4; Dead box protein 4; Dead-box protein 4; MGC111074; MVH; Probable ATP dependent RNA helicase DDX4; VASA; VASA homolog; DDX4_HUMAN. |
反应物种(已验证) |
Mouse |
反应物种(预测) |
Human,Rat,Pig,Cow |
产品应用(已验证) |
WB |
产品应用(可推荐) |
IHC,ELISA |
推荐稀释比例 |
WB=1:500-1000,Elisa=1:5000-10000,IHC-P=1:10-50, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
79 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human DDX4 C-term |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Cytoplasm, perinuclear region. |
Tissue |
Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes. |
SIMILARITY |
Belongs to the DEAD box helicase family. DDX4/VASA subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. |
SUBUNIT |
Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. N-terminus interacts with RANBP9. Interacts with PIWIL2 and MAEL. |
Function |
ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA m |
SWISS |
Q9NQI0 |
Gene ID |
54514 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |